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People who have thrombocytosis have normal platelets and a lower risk of blood clots and bleeding than people who have thrombocythemia. Thrombocytosis is more common than. When evaluating a patient with thrombocytosis, the key consideration is to exclude ET and CML 21 from reactive or inherited thrombocytosis and other disorders. Essential thrombocythemia is a diagnosis of exclusion and should be considered in patients in whom common reactive causes of thrombocytosis and other myeloproliferative. Whats the difference between essential thrombocythemia and thrombocytosis? If you have essential thrombocythemia, you have a high platelet count that isnt related to another medical.